.common-section.blue-bg .twocol-wrapper:first-child {
    padding-bottom: 24px;
}
.mii-sideeffects h3{
    color: #230B55;
    font-family: 'HelveticaLight';
    font-weight: 300;
    padding: 0px 0px 48px;
}
.mii-sideeffects .inner-study .mii-left h4{
    font-family: "HelveticaLight";
    font-size: 28px;
    line-height: 33px;
    font-weight: 300;
    font-style: normal;
    color: #191919;
    margin-bottom: 20px;
    padding-bottom: 0px;
}
.during-treatment-section h3.title-head{
    color: #230B55;
    font-family: "HelveticaNeueBold";
    font-size: 32px;
    font-style: normal;
    font-weight: 500;
    line-height: normal;
    letter-spacing: 1.6px;
    margin-bottom: 48px;
}
.during-treatment-section h4.sub-head-title{
    color: #230B55;
    font-family: "HelveticaNeue";
    font-size: 28px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    letter-spacing: 0.56px;
    margin-top: -5px;
    margin-bottom: 12px;
}
.tips-for-managing-section h3{
    font-size: 32px;
    line-height: 39px;
    color: #FAFAFA;
    font-weight: 500;
    font-style: normal;
    margin-bottom: 16px;
    font-family: 'HelveticaNeueBold';
}
.tips-for-managing-section h4.accordion-header{
    margin-bottom: 0;
}
.three-col-plane-section .three-col-plane-section-body h3{
    font-size: 32px;
    line-height: 39px;
    font-style: normal;
    font-weight: 500;
    margin-bottom: 24px;
    color: #230B55;
    font-family: 'HelveticaNeueBold';
}
.three-col-plane-section.healthcare-section .four-col-section-item h3.careHead{
    color: #230B55;
    font-family: 'HelveticaNeueBold';
    font-weight: 500;
    margin-top: 16px;
    margin-bottom: 0;
    font-size: 32px;
    line-height: 39px;
}
.possible-body h3{
    color: #230B55;
    font-size: 32px;
    line-height: 39px;
    font-weight: 500;
    font-style: normal;
    margin-bottom: 24px;
    font-family: 'HelveticaNeueBold';
}
.three-col-plane-section .three-col-plane-section-body h3{
    font-size: 32px;
    line-height: 39px;
    font-style: normal;
    font-weight: 500;
    margin-bottom: 24px;
    color: #230B55;
    font-family: 'HelveticaNeueBold';
}
@media (min-width: 320px) and (max-width: 992px) {
    .tips-for-managing-section h3 br {
        display: none;
    }
    .three-col-plane-section .three-col-plane-section-body h3{
        font-size: 26px;
        line-height: 32px;
    }
    .possible-body h3{
        font-size: 26px;
        line-height: 32px;
    }
    .three-col-plane-section .three-col-plane-section-body h3{
        font-size: 26px;
        line-height: 32px;
    }
    .tips-for-managing-section h3{
        font-size: 26px;
        line-height: 32px;
    }
    .during-treatment-section h4.sub-head-title{
        font-family: "HelveticaLight";
        font-size: 26px;
        font-weight: 300;
        line-height: 32px;
        letter-spacing: 1.3px;
        margin-top: 36px;
        margin-bottom: 36px;
    }
    .during-treatment-section h3.title-head {
        font-size: 26px;
        line-height: 32px;
        letter-spacing: 1.3px;
        margin-top: 36px;
    }
    .mii-sideeffects h3 {
        font-size: 26px;
        line-height: 32px;
        padding: 0px 0px 36px;
        margin-bottom: 0;
    }
    .mii-sideeffects .inner-study .mii-left h4{
        font-size: 22px;
        line-height: 28px;
        margin-bottom: 28px;
    }
}
/* new css added for new potential side effects*/
.three-col-plane-section.healthcare-section,.common-section.possible-section{
	background:#fafafa;
}
p.Font16 {
    font-size: 16px !important;
    line-height: 24px !important;
}
div#accordionPanelsStayOpenExample ul.followUp-list ul.pl-0 {
    padding-left: 0;
}
.three-col-plane-section.healthcare-section .four-col-section-item {
    background: transparent;
}
.orabgeBar {
    width: 100%;
    margin-top: -2px;
    float: left;
}
.common-banner-body ul li a{
	font-weight: 500;
    font-family: 'HelveticaNeueBold';
}
.three-col-plane-section .three-col-plane-section-body h2,.possible-body h2{
	color: #230B55;
}
body {
    line-height: normal;
}
.side-two-col-section {
    padding: 48px 0 48px;
}
.tips-for-managing-section,.tips-for-managing-section .rightSide {
    position: relative;
}
.tips-for-managing-section .rightSide::before {
    content: "";
    left: 0;
    width: 100%;
    height: 100%;
    top: 0;
    bottom: 0;
    position: absolute;
    z-index: 1;
    background: url(../images/shadow-image.png);
    background-repeat: no-repeat;
}
.two-col-mii-body .bottomborder::after {
    bottom: -12px;
}
.during-treatment-section .two-col-section-body .followUp-list {
    margin-bottom: 24px;
}
#tips-for-managing-side-effects .notanactual {
    position: absolute;
    right: 4%;
    bottom: 1%;
    color: #FAFAFA;
    font-size: 12px;
    font-family: "HelveticaNeue";
    font-weight: 400;
    z-index: 1;
}
.mii-sideeffects{
	background: #FAFAFA;
	padding: 40px 0 80px;
}
.mii-right {
    border-radius: 4px;
    border: 1px solid #230B55;
}
ul.followUp-list li::before {
    color: #191919;
}
.during-treatment-section {
    background: #E8E8E8;
	padding-bottom:80px;
}
.during-treatment-section h2.sub-head-title,
.during-treatment-section h2.title-head{
	color:#230B55;
}
.during-treatment-section ul.followUp-list li{
	margin-bottom:5px;
	font-size: 18px;
    line-height: 26px;
}
.during-treatment-section .two-col-right p {
    font-size: 18px;
    line-height: 26px;
	margin-top: 0px;
    margin-bottom: 12px;
}
.during-treatment-section .notanactual-right {
    right: 4%;
	left:auto;
	color:#fafafa;
}
.accordion-button:not(.collapsed) {
    color: #230B55;
}
.accordion-button:not(.collapsed)::after {
    background-image: url(../images/pantumor/minus-solid.png);
	width: 30px;
    height: 34px;
}
.accordion-button::after {
    background-image: url(../images/pantumor/plus-solid.png);
	width: 30px;
    height: 34px;
	background-size: contain;
}
.possible-body h2 {
    color: #230B55;
}
#tips-for-managing-side-effects .leftSide {
    position: relative;
    z-index: 2;
}
#tips-for-managing-side-effects img.w-100.img-fluid.desktopViewOnly.position-relative {
    object-fit: cover;
    height: 100%;
}
.accordionPanels p.accordion-head-title {
    margin-bottom: 50px;
}
.three-col-plane-section.healthcare-section .four-col-section-item h2,
.three-col-plane-section.healthcare-section .four-col-section-item h3,
.possible-body h2 {
    color: #230B55;
}
.three-col-plane-section.healthcare-section .four-col-section-item{
	background:#fafafa;
}
a.download-guide {
    font-family: 'HelveticaNeue-Medium';
    color: #6734AC;
    text-decoration: underline;
}
.possible-body ul.followUp-list li{
	margin-bottom:12px;
}
.mii-right{
	background: #FAFAFA;
}
.mii-sideeffects h2{
	color: #230B55;
	padding: 0px 0px 48px;
}
.mii-sideeffects {
    padding: 48px 0 80px;
}
.common-banner{
    background: #F4F4F4;
}
.accordion-button {
	color: #230B55;
	}
.twocol-wrapper-left {
    background-color: #F4F1FA;
}
.twocol-wrapper-right {
    background: #FAFAFA;
}	
.twocol-wrapper-right p {
    color: #260859;
}
.default_btn .fa-angle-right:before {
    width: 24px;
    height: 24px;
}

.common-section.possible-section{
	border-top:none;
}
.top-header-links li:last-child {
    padding-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    text-align: inherit;
}
.nav-down-arrow{
	background: url(../images/arrow-down.png) no-repeat 0 0 #EA721F;
	height:24px;
	top: 0px;
	width:18px;
}
.nav-down-arrow:hover{
    background: #C35F1A !important;
}
.common-section.possible-section {
    padding-top: 0px;
}
.mii-sideeffects h2 {
    color: #230B55;
    font-family: 'HelveticaLight';
    font-weight: 300;
}
li.dropdown.supportResource ul.dropdown-menu.show {
    padding: 0;
    transform: translate3d(0px, 67px, 0px) !important;
} 
div#enehrtudownload h2 {
    color: #230B55;
}
.enehrtu4uSection .lib-item .left-img{
	border: #230B55 1px solid;
}
.bottomborder::after{
	background: #EA721F;
}
.note p {
    font-size: 12px !important;
}
.spacingTop80{
	padding-top:80px !important;
}
#enhertu4U .notanactual-right{
	right:4%;
	left:inherit;
}
/*----ISI Start------*/
.isi-head {
    border-bottom: none;
    background: #230B55;
}
.isi-head a#isi{
	color:#fff;
}
.isi-head span.up-arrow, .isi-head span.down-arrow{
	background: url(../images/pantumor/isi-up-arrow.png) no-repeat 0 0 transparent;
}
.isi-content .boldText{
	color:#230B55;
}
.isi-content .followUp-list ul li::before,
.isi-content .followUp-list li::before {
    color: #191919;
}
.isi-content .followUp-list ul.followUp-list {
    margin-top: 8px;
}
.isi-content .leftLineBar::before {
    background: #191919;
}
.isi_new {
    padding-bottom: 64px;
    background: #fff;
}


.isi-head span.up-arrow {
    transform: rotate(180deg);
    -webkit-transform: rotate(180deg);
    -ms-transform: rotate(180deg);
}

.isi-content {
    padding-top: 17px;
}

.isi-content p {
    font-size: 16px;
    line-height: 24px;
    color: #191919;
    margin-bottom: 8px;
}

.isi-content .boldText {
    font-size: 16px;
    line-height: 24px;
    font-family: 'HelveticaNeueBold';
}

.isi-content ul.followUp-list {
    padding-left: 0;
    margin-bottom: 16px;
}

.isi-content .followUp-list li {
    line-height: 24px;
    font-size: 16px;
    position: relative;
    padding-left: 15px;
    color: #191919;
    margin: 0;
}

.isi-content .followUp-list li::before {
    content: "\2022";
    font-size: 12px;
    position: absolute;
    left: 0px;
    font-family: 'HelveticaNeueBold';
    top: 0px;
}

.isi-content .followUp-list ul {
    padding-left: 10px;
}

.isi-content .followUp-list ul.followUp-sublist {
    margin-top: 8px;
}

.isi-content .followUp-list ul.followUp-sublist li {
    margin-top: 8px;
}


.isi-content .followUp-list ul li::before {
    font-size: 16px;
    position: absolute;
    left: 0px;
    font-family: 'HelveticaNeueBold';
    top: 0;
    content: "◦";
}
.isi-content .followUp-list ul.followUp-list {
    padding-left: 0;
}
.isi-content .underline {
    text-decoration: underline;
}

.isi-content a.underline {
    text-decoration: underline;
}

.isi-content .leftLineBar {
    position: relative;
    padding-left: 15px;
}

.isi-content .leftLineBar::before {
    position: absolute;
    left: 0px;
    top: 6px;
    width: 1px;
    height: 100%;
    content: "";
}

#bottom {
    z-index: 3;
    width: 100%;
}

/*----ISI End------*/
@media (min-width: 320px) and (max-width: 992px) {
.accordion-button:not(.collapsed)::after{
	transform: translateY(22px);
}	
.accordion-button::after {
    right: 10px;
	transform: translateY(22px);
}
.side-two-col-section #potential-side-effects h2 {
	margin-top: 0;
	margin-bottom: 24px;
}	
.two-col-mii-body .bottomborder::after {
	bottom: -16px !important;
}	
p.bottomborder br,.tips-for-managing-section h2 br{
        display: none;
    }	
.mii-sideeffects h2 {
    padding: 0px 0px 36px;
	margin-bottom: 0;
}
.mii-sideeffects {
	padding: 36px 0 80px !important;
}
.during-treatment-section h2.sub-head-title{
	margin-top:36px!important;
}
.possible-body ul.followUp-list li {
    margin-bottom: 0px;
}
.possible-section .possible-body .followUp-list li:last-child {
    padding-bottom: 0px !important;
}
}