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What is ENHERTU?

ENHERTU is a prescription medicine used to treat adults who have non-small cell lung cancer (NSCLC) that has a certain mutation in the HER2 gene and cannot be removed by surgery or has spread to other parts of your body (metastatic), and who have received a prior treatment. Your healthcare provider will perform a test to make sure ENHERTU is right for you.

  • ENHERTU was FDA approved for this use based on a clinical study that measured how many patients responded and how long they responded. ENHERTU is still being studied to confirm these results.

It is not known if ENHERTU is safe and effective in children.

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How is ENHERTU thought to work?

As a targeted treatment called an antibody-drug conjugate (ADC), ENHERTU is designed to work differently than traditional chemotherapies.

Antibody graphic

ENHERTU is made up
of an antibody with
the chemotherapy
attached

Antibody and cancer cell graphic

The antibody part of
ENHERTU targets and
attaches to HER2 on
the cancer cell

Cancer cell graphic

ENHERTU enters
the cancer cell and the
chemotherapy is released

Destroy cancer cell graphic

The chemotherapy part
of ENHERTU helps
destroy the cancer cell
as well as other
cells nearby

Although ENHERTU is designed to target HER2 on cancer cells, it may affect some healthy cells. ENHERTU may not work for everyone.

How will I receive ENHERTU?

ENHERTU is given as an intravenous (IV) infusion. You will receive an ENHERTU infusion once every 3 weeks, either at your oncologist’s office or at a nearby infusion center.

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Your healthcare provider will give you medicines before your infusion to help prevent nausea and vomiting

First infusion – 90 minutes

The first ENHERTU infusion will take about 90 minutes so the healthcare provider can monitor any potential reactions

Second infusion(s) – 30 minutes

Future ENHERTU infusions should take about 30 minutes if your first infusion was well tolerated

If you miss a planned dose of ENHERTU, call your healthcare provider right away to schedule an appointment.
Do not wait until the next planned treatment cycle.

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Starting treatment with ENHERTU? Learn more about ENHERTU, including Important Safety Information

HER2, human epidermal growth factor receptor 2.