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What is ENHERTU?

ENHERTU is a prescription medicine used to treat adults who have:

  • Human epidermal growth factor receptor 2 (HER2)-low breast cancer that cannot be removed by surgery or that has spread to other parts of the body (metastatic), and who have received a prior chemotherapy
    • for metastatic disease, or
    • whose disease has returned during or within 6 months of completing adjuvant chemotherapy (after surgery).
  • Hormone receptor (HR)-positive, HER2-low or HR-positive, HER2-ultralow, breast cancer that cannot be removed by surgery or that has spread to other parts of the body (metastatic), and who have received one or more endocrine treatments for metastatic disease.

Your healthcare provider will perform a test to make sure ENHERTU is right for you.

It is not known if ENHERTU is safe and effective in children.

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How is ENHERTU thought to work?

As a targeted treatment called an antibody-drug conjugate (ADC), ENHERTU is designed to work differently than traditional chemotherapies.

Antibody graphic Antibody graphic

ENHERTU is made up of an antibody with the chemotherapy attached

Antibody and cancer cell graphic Antibody and cancer cell graphic

The antibody part of ENHERTU targets and attaches to HER2 on the cancer cell

Cancer cell graphic Cancer cell graphic

ENHERTU enters the cancer cell and the chemotherapy is released

Destroy cancer cell graphic Destroy cancer cell graphic

The chemotherapy part of ENHERTU helps destroy the cancer cell as well as other cells nearby

Although ENHERTU is designed to target HER2 on cancer cells, it may affect some healthy cells. ENHERTU may not work for everyone.

How will I receive ENHERTU?

ENHERTU is given as an intravenous (IV) infusion once every 3 weeks.

You will receive an ENHERTU infusion either at your oncologist's office or at a nearby infusion center.

Pill in hand

Your healthcare provider will give you medicines before your infusion to help prevent nausea and vomiting

First infusion – 90 minutes

The first ENHERTU infusion will take about 90 minutes so the healthcare provider can monitor any potential reactions

Second infusion(s) – 30 minutes

Future ENHERTU infusions should take about 30 minutes if your first infusion was well tolerated

If you miss a planned dose of ENHERTU, call your healthcare provider right away to schedule an appointment. Do not wait until the next planned treatment cycle.

If you experience side effects, your doctor may treat the side effect, delay your dose, reduce your dose, or stop ENHERTU.

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HER2, human epidermal growth factor receptor 2.