UNDERSTANDING HER2-LOW
AND HR+, HER2-ULTRALOW mBC

Woman looking straight ahead 1

If you were previously diagnosed with HER2-negative metastatic breast cancer, you may actually have low HER2 levels

HER2 is a protein that tells cells to grow. When cells produce too much HER2, they can become cancerous.

Woman looking straight ahead 1

In people with breast cancer, HER2 status used to be thought of like an on/off switch: HER2-positive or HER2-negative. Now it is thought to be more like a dimmer.

Spectrum from negative to positive graphic Spectrum from negative to positive graphic

Some doctors now recognize HER2-low and HER2-ultralow as subsets of HER2-negative.

Having HER2-low or HER2-ultralow means that there is a low level of HER2 on cancer cells but not enough HER2 to be considered HER2-positive.

If your HER2-negative mBC stops responding to endocrine (hormone) treatment, ask your doctor if you have low levels of HER2.

Woman looking straight ahead 2

Your doctor can evaluate your HER2 levels to determine if a therapy designed to target HER2 on cancer cells, like ENHERTU, is right for you.

If your doctor told you that you have HER2-negative mBC, ask if your HER2 immunohistochemistry (IHC) score could indicate a diagnosis of HER2-low or HER2-ultralow mBC.

HER2 status is different than hormone receptor (HR) status. People with low levels of HER2 can be either HR positive or HR negative.

Learn more about ENHERTU4U

Learn more about HER2-low or HER2-ultralow mBC

Sign up for information

Would you like to receive updates
about ENHERTU?

HER2, human epidermal growth factor receptor 2.